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KMID : 1211620100050020273
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Journal of the Korean Society of Physical Medicine
2010 Volume.5 No. 2 p.273 ~ p.280
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Effect of Low Frequency Electrical Stimulation on VEGF Expression of Suspension Induced Atrophic Muscle
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Kang Jong-Ho
Han Jong-Man
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Abstract
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Purpose: The purpose of this experiment was to evaluate the pre-application effect of low frequency electrical stimulation(LFES) on VEGF expression of atrophic muscle and to determine the optimal pre-application period of LFES for prevent muscle atropy
Methods: Twenty-five adult sprague-dawley rats were randomly assigned to weight bearing group, hindlimb suspension for 14 days group, hindlimb suspension with pre-application of LFES for 14 days group, hindlimb suspension with pre-application of LFES for 11 dsys group and, hindlimb suspension with pre-application LFES for 7 dsys group. 16Hz of Biphasic pulse current was applied to gastrocnemius for 15min per days.
Results: VEGF were decreased expression in HSG groups, whereas VEGF were significantly increased in HS+ES14G, HS+ES11G, HS+ES7G groups
Conclusion: LFES during the hindlimb suspension showed a positive effect in VEGF induction and early application is strongly encourage VEGF induction. This indicated that pre-application of LFES could prevent muscle atrophy.
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KEYWORD
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Muscle atrophy, Low frequency electrical stimulation, Vascular endothelial growth factor
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